John E. Collins Gene Annotations. John E. Collins Trust Genome Campus. John E. Collins Project Scientific Reports.
Tuesday, April 5, 2011
"Jennifer L. Ashurst and John E. Collins
John E Collins, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton
Cambridge CB10 1SA, United Kingdom; email: jla1@sanger.ac.uk
John E Collins Key Words human genome, manual annotation, ab initio prediction
n Abstract Fifty years after the publication of DNA structure, the whole human
genome sequence will be officially finished. John E Collins, This achievement marks the beginning of
the task to catalogue every human gene and identify each of their function expression
patterns.
* John E. Collins *
John E Collins Currently, researchers estimate that there are about 30,000 human genes
and approximately 70% of these can be automatically predicted using a combination
of ab initio and similarity-based programs.
John E Collins However, to experimentally investigate every gene’s function, the research community requires a high-quality annotation of alternative splicing, pseudogenes, and promoter regions that can only be provided by manual intervention. John E Collins, Manual curation of the human genome will be a long-term project as experimental data are continually produced to confirm or refine the predictions, and new features such as noncoding RNAs and enhancers have not been fully identified.
Such a highly curated human gene-set made publicly available will be a great asset for the experimental community and for future comparative genome projects." ~ John E. Collins
Source of John E. Collins Post
http://dimer.tamu.edu/genomics/ra/03_Third_Lecture/03_Reading_for_Lecture_A.pdf
