John E. Collins Gene Annotations. John E. Collins Trust Genome Campus. John E. Collins Project Scientific Reports.

John E. Collins

"Jennifer L. Ashurst and John E. Collins

John E Collins, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton

Cambridge CB10 1SA, United Kingdom; email: jla1@sanger.ac.uk

John E Collins Key Words human genome, manual annotation, ab initio prediction

n Abstract Fifty years after the publication of DNA structure, the whole human

genome sequence will be officially finished. John E Collins, This achievement marks the beginning of

the task to catalogue every human gene and identify each of their function expression

patterns.

* John E. Collins *

John E Collins Currently, researchers estimate that there are about 30,000 human genes

and approximately 70% of these can be automatically predicted using a combination

of ab initio and similarity-based programs.

John E Collins However, to experimentally investigate every gene’s function, the research community requires a high-quality annotation of alternative splicing, pseudogenes, and promoter regions that can only be provided by manual intervention. John E Collins, Manual curation of the human genome will be a long-term project as experimental data are continually produced to confirm or refine the predictions, and new features such as noncoding RNAs and enhancers have not been fully identified.

Such a highly curated human gene-set made publicly available will be a great asset for the experimental community and for future comparative genome projects."  ~ John E. Collins

Source of John E. Collins Post

http://dimer.tamu.edu/genomics/ra/03_Third_Lecture/03_Reading_for_Lecture_A.pdf

John E. Collins